Medical Use

hmm, if you consider just how much morpheney weenie I, your humble narrator, personally eats on a daily basis I am thinking there may be a money saving for us somewheres. Ahh, no. Active Ingredient In Cannabis Eliminates Morphine Dependence In Rats ScienceDaily (July 15, 2009) — Injections of THC, the active principle of cannabis, eliminate dependence on opiates (morphine, heroin) in rats deprived of their mothers at birth. The findings could lead to therapeutic alternatives to existing substitution treatments. In order to study psychiatric disorders, neurobiologists use animal models, especially maternal deprivation models. Depriving rats of their mothers for several hours a day after their birth leads to a lack of care and to early stress. The lack of care, which takes place during a period of intense neuronal development, is liable to cause lasting brain dysfunction. The study was carried out by Valérie Daugé and her team at the Laboratory for Physiopathology of Diseases of the Central Nervous System (UPMC / CNRS / INSERM). Valérie Daugé's team at the Laboratory for Physiopathology of Diseases of the Central Nervous System (UPMC / CNRS / Inserm) analyzed the effects of maternal deprivation combined with injections of tetrahydrocannabinol, or THC, the main active principle in cannabis, on behavior with regard to opiates. Previously, Daugé and her colleagues had shown that rats deprived of their mothers at birth become hypersensitive to the rewarding effect of morphine and heroin (substances belonging to the opiate family), and rapidly become dependent. In addition, there is a correlation between such behavioral disturbances linked to dependence, and hypoactivity of the enkephalinergic system, the endogenous opioid system. To these rats, placed under stress from birth, the researchers intermittently administered increasingly high doses of THC (5 or 10 mg/kg) during the period corresponding to their adolescence (between 35 and 48 days after birth). By measuring their consumption of morphine in adulthood, they observed that, unlike results previously obtained, the rats no longer developed typical morphine-dependent behavior. Moreover, biochemical and molecular biological data corroborate these findings. In the striatum, a region of the brain involved in drug dependence, the production of endogenous enkephalins was restored under THC, whereas it diminished in rats stressed from birth which had not received THC. Such animal models are validated for understanding the neurobiological and behavioral effects of postnatal conditions in humans. In this context, the findings point to the development of new treatments that could relieve withdrawal effects and suppress drug dependence. The enkephalinergic system produces endogenous enkephalins, which are neurotransmitters that bind to the same receptors as opiates and inhibit pain messages to the brain. I still have a broken back, three broken ribs (healed by now) and six fused vertebrae and the list goes on... so I will probo continue to be forced to take my methadone and smoke pot to control the nausea and other horrid crap ill people like myself endure. I intend to live even tho there are days when I think it's a questionable idea because of all the idiots required to deal with just to stay alive. At least I have brains and courage enough to grow and smoke my pot which helps me in so many ways. You see, pot enhances many downers and so I can take less of these awful killers and still get good effect. And, like many thousands of other hurt and ill peeps of the world, that's a good thing. The bad thing, of course, is that I live in a pot nazi controlled area headed up by pot-nazi Obergruppenfuher Chaz-ley Grassley, himself. A true hick and genuine asshole senator for my beloved Iowa. The good thing for him is: he has me, your determined if humble narrator (heh). The bad thing for him is: I refuse to die first and he is a really old bastard. I intend to smoke pot and piss on his grave soon after so he can get his richly deserved THC sendoff. God Bless You Everyday, Carl Olson, you make me proud.